
Withdrawal
{What to expect when you stop taking certain drugs}
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Opioid withdrawal
As the use of opioids causes comfort and relaxation, withdrawal from opioids is very unpleasant although usually not life threatening. The symptoms usually begin around 6-30 hours after last use, and symptoms are worse in the later stages i.e. 72 hours onwards and last for around a week. Psychological symptoms tend to last longer than the physical symptoms. For some users it might be helpful to have support through this as it can be difficult to maintain resilience throughout withdrawal, however this isn't always an issue for everyone.
Withdrawal effects can be managed with pharmacological interventions, such as opioid substitution treatment or medically assisted detoxification, but it's also beneficial to have psychosocial support alongside these. People who use opiates or opioids to manage trauma may find withdrawal even more difficult because of having to deal with these feelings without the comfort provided by the drug.
Symptoms of opioid withdrawal
Physical symptoms
- rapid pulse
- insomnia
- muscle cramps/tremor
- diarrhoea
- fever/chills
Psychological symptoms
- anxiety
- irritability
- anhedonia (decrease in pleasure from life)
References: Kosten T et al. 2002; Elsevier
References
Nathan B. Eddy M. Drug dependence: its significance and characteristics [Internet]. PubMed Central (PMC). 2020 [cited 27 April 2020]. Available from: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555251/>
Drug addiction: getting help [Internet]. nhs.uk. 2020 [cited 27 April 2020]. Available from: <https://www.nhs.uk/live-well/healthy-body/drug-addiction-getting-help/>
Conroy D, Arnedt J. Sleep and Substance Use Disorders: An Update. Current Psychiatry Reports. 2014;16(10).
Differential Effects of Addictive Drugs on Sleep and Sleep Stages. Journal of Addiction Research. 2019;3(2).
Sleep Hygiene - The Sleep Council [Internet]. The Sleep Council. 2020 [cited 27 April 2020]. Available from: <https://sleepcouncil.org.uk/advice-support/sleep-advice/sleep-hygiene/>
McKeown, DO N. Withdrawal Syndromes: Practice Essentials, Background, Pathophysiology [Internet]. Emedicine.medscape.com. 2018 [cited 15 April 2020]. Available from: <https://emedicine.medscape.com/article/819502-overview#a6>
WHO | Withdrawal state [Internet]. Who.int. 2020 [cited 26 April 2020]. Available from: <https://www.who.int/substance_abuse/terminology/withdrawal/en/>
The Dangers of Medication Tolerance [Internet]. Verywell Mind. 2020 [cited 27 April 2020]. Available from: <https://www.verywellmind.com/medication-tolerance-1124101>
Nutt D. Drugs without the hot air. La Vergne: UIT Cambridge Ltd.; 2020. Pg 139-140
KFx Drug Consultancy Initiative. Drug Facts: Alcohol [Internet]. kfx.org.uk. 2010. Available from: <http://www.kfx.org.uk/drugfacts/drugfacts_alcohol.php?LMCL=Do0r2V>
Nutt D. Drink? The New Science of Alcohol + Your Health. London: Yellow Kite; 2020.
Becker HC. Effects of Alcohol Dependence and Withdrawal on Stress Responsiveness and Alcohol Consumption. Alcohol Research: Current Reviews [Internet]. 2012;34(4):448. Available from: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860383/>
Mammoser G. Alcohol Withdrawal: Cold Turkey Dangers [Internet]. Healthline. 2017. Available from: <https://www.healthline.com/health-news/cold-turkey-alcohol-withdrawal-can-cause-serious-health-issues#1>
Drinkaware [Internet]. drinkaware.co.uk. 2017. Available from: <https://www.drinkaware.co.uk/alcohol-facts/health-effects-of-alcohol/mental-health/alcohol-withdrawal-symptoms/>
Bayard M, McIntyre J, Hill KR, Woodside Jr J. Alcohol Withdrawal Syndrome. American Family Physician [Internet]. 2004 Mar 15;69(6):1443--50. Available from: <https://www.aafp.org/afp/2004/0315/p1443.html>
Cannabis Withdrawal & Detox Guide - UK Addiction Treatment Centres [Internet]. UK Addiction Treatment Centres. 2020 [cited 25 April 2020]. Available from: <https://www.ukat.co.uk/cannabis-detox/>
How Long Does Withdrawal From Marijuana Last? [Internet]. Verywell Mind. 2020 [cited 26 April 2020]. Available from: <https://www.verywellmind.com/what-to-expect-from-cannabis-withdrawal-22304>
Marijuana withdrawal: Symptoms, timeline, and tips for coping [Internet]. Medicalnewstoday.com. 2020 [cited 26 April 2020]. Available from: <https://www.medicalnewstoday.com/articles/324301#withdrawal-symptoms>
Hartney E. How Long Does Withdrawal From Marijuana Last? [Internet]. Verywell Mind. 2020 [cited 25 April 2020]. Available from: <https://www.verywellmind.com/what-to-expect-from-cannabis-withdrawal-22304>
Barcott B. Cannabis withdrawal syndrome: How to ease the symptoms [Internet]. Leafly. 2017 [cited 23 April 2020]. Available from: <https://www.leafly.com/news/health/cannabis-withdrawal-syndrome-ease-symptoms>
Bahji A, Stephenson C, Tyo R, Hawken E, Seitz D. Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids. JAMA Network Open [Internet]. 2020;3(4):e202370. Available from: <https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764234>
What is Spice and why is the drug so dangerous? [Internet]. The Conversation. 2016 [cited 26 April 2020]. Available from: <https://theconversation.com/what-is-spice-and-why-is-the-drug-so-dangerous-60600>
Legg TJ. My Addiction to Benzos Was Harder to Overcome Than Heroin [Internet]. Healthline. 2018. Available from: <https://www.healthline.com/health/addiction-drug-problem-benzos#1>
Bateson A. Basic Pharmacologic Mechanisms Involved in Benzodiazepine Tolerance and Withdrawal. Current Pharmaceutical Design. 2002 Jan 1;8(1):5--21.
Pétursson H. The benzodiazepine withdrawal syndrome. Addiction. 1994 Nov;89(11):1455--9.
Hu X. Benzodiazepine withdrawal seizures and management. J Okla State Med Assoc. 2011 Feb;104(2):62--5.
Ashton H. Benzodiazepines: How They Work & How to Withdraw [Internet]. benzo.org.uk. 2002. Available from: <https://benzo.org.uk/manual/bzcha02.htm>
GHB/GBL "G" - Let's Talk about It [Internet]. Let's Talk about It. 2020 [cited 28 April 2020]. Available from: <https://www.letstalkaboutit.nhs.uk/other-services/chemsex-support/ghbgbl-g/>
Kosten T, George T. The Neurobiology of Opioid Dependence: Implications for Treatment. Science & Practice Perspectives. 2002;1(1):13-20.
Opioid Withdrawal [Internet]. Elsevier.com. 2020 [cited 27 April 2020]. Available from: <https://www.elsevier.com/_data/assets/pdffile/0019/537031/opioid-withdrawal-ClinicalKey.pdf>
Treatment of Stimulant Use Disorders: Current practices and promising perspectives. [Internet]. Unodc.org. 2019. Available from: <https://www.unodc.org/documents/drug-prevention-and-treatment/TreatmentofPSUDforwebsite_24.05.19.pdf>
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