LSD
{Acid, Tab, Lucy, Lysergic acid diethylamide}
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Effects
Here are the most common effects, not everyone necessarily experiences all of them every time they consume the drug and other effects not listed might be felt. The likelihood of experiencing negative effects is far greater at high doses.
The effects are (from positive to negative):
Euphoria1
Positive mood
Loss of the sense of self
Distortions and hallucinations (visual, even with closed eyes; tactile, olfactory and auditory)
Changes in consciousness
Suggestibility
Spiritual or mystical experiences (entheogenic)
Unexpected emotions
Synaesthesia-like experiences
Visual hallucinations
Time travelling/time distortions
Confusion
Disorientation
Psychosis-like symptoms
Unpleasant feeling
Paranoid delusions
Anxiety
References
1 Carhart-Harris, R. L., Kaelen, M., Bolstridge, M., Williams, T. M., Williams, L. T., Underwood, R., ... & Nutt, D. J. (2016). The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychological medicine, 46(07), 1379-1390.
2 Carbonaro, T. M., Bradstreet, M. P., Barrett, F. S., MacLean, K. A., Jesse, R., Johnson, M. W., & Griffiths, R. R. (2016). Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences. Journal of Psychopharmacology, 30(12), 1268-1278.
3 Murray, R. M., Paparelli, A., Morrison, P. D., Marconi, A., & Di Forti, M. (2013). What can we learn about schizophrenia from studying the human model, drug?induced psychosis?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(7), 661-670.
4 Network, NEPTUNE. Guidance on the clinical management of acute and chronic harms of club drugs and novel psychoactive substances. 2015 http://neptune-clinical-guidance.co. uk/wp-content/uploads/2015/03.NEPTUNE-Guidance-March-2015.pdf)
5 Kaelen, M., Barrett, F. S., Roseman, L., Lorenz, R., Family, N., Bolstridge, M., ... & Carhart-Harris, R. L. (2015). LSD enhances the emotional response to music. Psychopharmacology, 232(19), 3607-3614.
6 Kaelen, M., Roseman, L., Kahan, J., Santos-Ribeiro, A., Orban, C., Lorenz, R., ... & Wall, M. B. (2016).LSD modulates music-induced imagery via changes in parahippocampal connectivity. European Neuropsychopharmacology, 26(7), 1099-1109.
7 Lebedev, A. V., Kaelen, M., Lövdén, M., Nilsson, J., Feilding, A., Nutt, D. J., & Carhart‐Harris, R. L. (2016). LSD‐induced entropic brain activity predicts subsequent personality change. Human brain mapping, 37(9), 3203-3213.
8 Speth, J., Speth, C., Kaelen, M., Schloerscheidt, A. M., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2016). Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide. Journal of Psychopharmacology, 30(4), 344-353.
9 Leary, T., Metzner, R., & Dass, R. (1966).The psychedelic experience.Smithsonian Folkways Recordings.
10 Carhart-Harris, R. L., Kaelen, M., Whalley, M. G., Bolstridge, M., Feilding, A., & Nutt, D. J. (2015). LSD enhances suggestibility in healthy volunteers. Psychopharmacology, 232(4), 785-794.
11 Tagliazucchi, E., Roseman, L., Kaelen, M., Orban, C., Muthukumaraswamy, S. D., Murphy, K., ... & Bullmore, E. (2016).Increased global functional connectivity correlates with LSD-Induced ego dissolution. Current Biology,26(8), 1043-1050.
12 Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., ... & Leech, R. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging.Proceedings of the National Academy of Sciences, 113(17), 4853-4858.
13 Roseman, L., Sereno, M. I., Leech, R., Kaelen, M., Orban, C., McGonigle, J., ... & Carhart‐Harris, R. L. (2016). LSD alters eyes‐closed functional connectivity within the early visual cortex in a retinotopic fashion.Human brain mapping, 37(8), 3031-3040.
14 Terhune, D. B., Luke, D. P., Kaelen, M., Bolstridge, M., Feilding, A., Nutt, D., ... & Ward, J. (2016). A placebo-controlled investigation of synaesthesia-like experiences under LSD. Neuropsychologia.
15 Family, N., Vinson, D., Vigliocco, G., Kaelen, M., Bolstridge, M., Nutt, D. J., & Carhart-Harris, R. L. (2016). Semantic activation in LSD: evidence from picture naming.Language, Cognition and Neuroscience, 1-8.
16 Dolder, P. C., Schmid, Y., Müller, F., Borgwardt, S., & Liechti, M. E. (2016). LSD acutely impairs fear recognition and enhances emotional empathy and sociality. Neuropsychopharmacology, 41(11), 2638.
17 Nichols, D. E. (2016). Psychedelics.Pharmacological reviews, 68(2), 264-355.
18 Strassman, R. J. (1984). Adverse reactions to psychedelic drugs. A review of the literature. J Nerv Ment Dis, 172(10), 577-595.
19 Halberstadt, A. L. (2015).Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behavioural brain research, 277, 99-120.
20 Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P., & Griffiths, R. R. (2014). Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Journal of Psychopharmacology, 0269881114548296
21 Garcia-Romeu, A., R Griffiths, R., & W Johnson, M. (2014). Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction.Current drug abuse reviews, 7(3), 157-164.
22 Krebs, T. S., & Johansen, P. Ø. (2013). Psychedelics and mental health: a population study. PloS one, 8(8), e63972.
23 Hendricks, P. S., Thorne, C. B., Clark, C. B., Coombs, D. W., & Johnson, M. W. (2015). Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. Journal of Psychopharmacology, 29(3), 280-288.
24 Johansen, P. Ø., & Krebs, T. S. (2015).Psychedelics not linked to mental health problems or suicidal behavior: A population study. Journal of Psychopharmacology, 0269881114568039.
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