This combination carries a low risk. Ibuprofen and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

This combination carries a low risk. Aspirin and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Taking both of these drugs together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively.

Taking both these drugs should not be harmful. The effects of both drugs are likely to be reduced.

Combining these drugs should not be harmful. However, they will mask each other’s effects, which might increase the risk of overdosing either drug. This combination is also hard on the heart due to each drug’s opposing action (7).

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Users have reported diminished experiences thus care should be taken with dosage.

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Users have reported diminished experiences, thus care should be taken with dosage.

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Benzos lessen the effects of nitrous oxide due to both drugs acting on common receptors.

We strongly recommend you avoid taking these drugs together, reactions are highly unpredictable and can be fatal. You will likely come to some degree of harm even if you take strong precautions.

Cannabis and DMT is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

Cannabis and LSD is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs.

The effects of mixing these two drugs together can be unpredictable.

Taking both these drugs together may produce unpleasant effects such as physical discomfort or overstimulation. High doses put you at risk. If you mix, start low and go slow

GHB and ketamine is an unsafe combination. Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

GHB and Nitrous is an unsafe combination. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs.

They will decrease the effects of 2C-B or may have unwanted side effects. People who take SSRIs are generally advised not to take psychedelics.

There is no evidence to date showing interactions between paracetamol and 2C-B.

This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is no evidence to date showing interactions between the contraceptive pill and MDMA. This combination is unlikely to cause an adverse or undesirable reaction when used carefully. However, MDMA will intensify and alter your mood. If your contraception is causing significant changes in your mood, it is advisable to avoid MDMA as it may intensify mood swings.

There is no evidence to date showing interactions between allergy medicines and modafinil. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Taking both these drugs together is likely to cause an effect stronger than taking them individually. If used with care they are unlikely to cause an adverse or undesirable reaction.

There is no evidence to date showing interactions between ibuprofen and MDMA. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between aspirin and benzos. This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is no evidence to date showing interactions between aspirin and modafinil. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Taking the combined oral contraceptive pill and cocaine together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively46,47.

There is a low risk when drinking a moderate amount of alcohol when using the recommended dose of aspirin.

Avoid alcohol if you are taking aspirin for a headache. Alcohol is likely to make a headache worse as it causes dehydration.

There is no evidence to date showing interactions between contraceptive pills and cannabis and generally this combination carries a low risk. However, cannabis will often intensify and alter your mood. If your contraception is causing significant changes in your mood, it is advisable to avoid cannabis as it may intensify mood swings.

There is no evidence to date showing interactions between contraceptive pills and ketamine. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

2C-X and GHB is not usually a harmful combination, it will tend to decrease the effects of both drugs.

Alcohol and GHB is an unsafe combination. Even in very low doses this rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.

We strongly recommend you avoid taking alcohol and ketamine together. Even mixing small amounts is likely to cause impaired coordination, nausea, vertigo, and “the spins”. There is a high risk of falling unconscious and vomiting which can be fatal if the person is not placed in the recovery position.

Be careful when mixing amphetamines and GHB. Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.

Avoid benzos if you are taking allergy medicines. benzos and allergy medicines such as Benadryl, Piriton and Clarityn are depressants and both slow down your central nervous system. This can produce heightened side effects such as drowsiness, sedation and poor concentration. In extreme cases, loss of consciousness and may occur.

These two drugs potentiate each other strongly and unpredictably which might lead to memory loss, blackout and respiratory depression.

SSRIs block the release of serotonin and can dull the effects of MDMA. This can lead people to take a potentially fatal overdose when they don't feel the effects.

Aspirin and MDMA taken together may cause a greater increase in body temperature and sweating than is normal. This poses the greatest risk when dancing in crowded conditions. Take a break periodically to cool down.

Using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before mixing drugs.

Effects will be stronger than taking either drug alone, however, it’s unlikely that there will be any adverse health reactions to this combination.

_Users report that the two herbs go well with each other, however, moderation is important when combining them. Keeping both doses low helps ensuring that you derive the highest possible positive effects without crossing the line to negative side-effects. You should go particularly light on cannabis dosage. Although rarely, some users report mild effects, such as feeling nauseous, sick and uncomfortable. Stronger side effects include anxiety and dizziness._

_Reactions and side effects are rare, but using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Kratom’s effects are due primarily to its interaction with mu-receptors in the brain, while SSRIs produce their effects by interacting with the serotonin receptors. It is hypothesized that, since both act on receptors that can sometimes be involved with each other in certain processes, an interaction may or may not occur. Interactions include risks such as_ [_serotonin syndrome_](https://www.mdedge.com/ccjm/article/120386/neurology/serotonin-syndrome-preventing-recognizing-and-treating-it)_. Additional research should always be done before mixing drugs._

Be careful when taking amphetamines (e.g. Adderall) and cocaine together. Both are stimulants, which increases the strain on your heart and places you at higher risk of overdosing. Cocaine will also mildly block the effects of the amphetamines4,21.

Be careful when taking benzos and cocaine together. Each drug can mask the effects of the other, making it easier to overdose, especially if one wears off before the other. If you use cocaine often, the effects of the benzos may be amplified so start low and go slow22,23.

Combining these drugs should not be harmful. However, the effects for both drugs are reduced, making it easier to overdose, since your 'psychological baseline' is shifted from what you are used to.

Benzodiazepines will decrease the effects of 2C-B.

Combining these drugs should not be harmful. However, they will mask each other’s effects, which might increase the risk of overdosing either drug.

This combination carries a low risk. Paracetamol and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is no evidence to date showing interactions between paracetamol and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between allergy medicines and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

[**Tramadol**](https://www.drugs.com/tramadol.html) can result in seizures when taken with LSD, as Tromadol lowers the seizure threshold.

These combinations are considered extremely harmful and should always be avoided. Reactions to combining these drugs are highly unpredictable and can potentially cause death.

MAO-B can potentiate and greatly increase the duration of all 2C-X drugs in an unpredictable way. alfa-MT is an MAOI itself and so combining it with many drugs can be extremely risky.

These combinations are considered extremely harmful and should always be avoided. Reactions to combining these drugs are highly unpredictable and can potentially cause death.

Tramadol lowers the seizure threshold and thus should not be combined with any psychedelics, MAOIs, amphetamines and substituted amphetamines, or other opioids.

There is no evidence to date showing interactions between ibuprofen and 2C-B. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

We strongly recommend you avoid taking MAOIs and cocaine. This combination will likely increase your blood pressure to dangerous levels and may put you in a [hypertensive crisis](https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/expert-answers/hypertensive-crisis/faq-20058491)39,40.

We strongly recommend you avoid taking opioids (e.g. heroin) and cocaine together (known as “speedballing”). This combination is often fatal. It will likely cause breathing difficulties and issues with heart rate38.

There is no evidence to date showing interactions between ibuprofen and benzos. This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is no evidence to date showing interactions between ibuprofen and modafinil. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Taking aspirin and cocaine together is not usually any more harmful than taking them individually. Aspirin is sometimes [used](https://www.the-hospitalist.org/hospitalist/article/125897/how-should-patient-cocaine-associated-chest-pain-be-treated) by doctors in response to cocaine associated chest pains51,52.

There is a low risk when drinking a moderate amount of alcohol when using the recommended dose of paracetamol.

Avoid alcohol if you are taking paracetamol for a headache. Alcohol is likely to make a headache worse as it causes dehydration.

Interactions

Check how pairs of drugs interact with each other when consumed.