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Taking both these drugs should not be harmful. The effects of both drugs are likely to be reduced.

We strongly recommend you avoid taking these drugs together, reactions are highly unpredictable and can be fatal. You will likely come to some degree of harm even if you take strong precautions.

Taking both of these drugs together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively.

Be careful when mixing amphetamines and GHB. Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.

There is no evidence to date showing interactions between allergy medicines and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between ibuprofen and 2C-B. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Taking both these drugs together is likely to cause an effect stronger than taking them individually. If used with care they are unlikely to cause an adverse or undesirable reaction.

_Users report that the two herbs go well with each other, however, moderation is important when combining them. Keeping both doses low helps ensuring that you derive the highest possible positive effects without crossing the line to negative side-effects. You should go particularly light on cannabis dosage. Although rarely, some users report mild effects, such as feeling nauseous, sick and uncomfortable. Stronger side effects include anxiety and dizziness._

Taking both these drugs together may produce unpleasant effects such as physical discomfort or overstimulation. High doses put you at risk. If you mix, start low and go slow

Amphetamines and DMT is not usually a harmful combination but stimulants generally increase anxiety levels and the risk of thought loops which can lead to negative experiences.

Tricyclics (Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, and Vivactil) is consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into a fugue state where they wander away from home and don't know how they got there, and they are generally in a terrible state psychologically. Life-threatening seizures and at least one death have been reported to be triggered by the combination of LSD and tricyclics. If you are prescribed tricyclics for mental health problems, it is not a good idea to try LSD outside of a supervised medical setting, as it might worsen the symptoms.

Using these drugs together can cause an effect stronger than desired though they aren't likely to cause a serious adverse reaction if used carefully. Additional research should always be done before mixing drugs.

Cannabis and mushrooms is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Users have reported diminished experiences thus care should be taken with dosage.

This combination carries a low risk. Ibuprofen and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is a low risk when drinking a moderate amount of alcohol when using the recommended dose of aspirin.

Avoid alcohol if you are taking aspirin for a headache. Alcohol is likely to make a headache worse as it causes dehydration.

_Reactions and side effects are rare, but using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Kratom’s effects are due primarily to its interaction with mu-receptors in the brain, while SSRIs produce their effects by interacting with the serotonin receptors. It is hypothesized that, since both act on receptors that can sometimes be involved with each other in certain processes, an interaction may or may not occur. Interactions include risks such as_ [_serotonin syndrome_](https://www.mdedge.com/ccjm/article/120386/neurology/serotonin-syndrome-preventing-recognizing-and-treating-it)_. Additional research should always be done before mixing drugs._

There is no evidence to date showing interactions between ibuprofen and ketamine. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Caffeine and GHB have low risk and decreased synergy. Caffeine will mildly hide the depressant effects of GHB leading to a slightly increased risk of overdose.

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs.

Effects will compound with each other, however, the effects of DMT will probably overpower that of 2C-B since it is a much more powerful hallucinogen.

Both drugs potentiate the sedation and impairment of coordinate caused by the other. High doses can lead to unexpected loss of consciousness

There is no evidence to date showing interactions between ibuprofen and modafinil. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between aspirin and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between contraceptive pills and cannabis and generally this combination carries a low risk. However, cannabis will often intensify and alter your mood. If your contraception is causing significant changes in your mood, it is advisable to avoid cannabis as it may intensify mood swings.

Avoid cannabis if you are taking allergy medicines. Benadryl, Piriton and Piriteze are known to have adverse effects when combined with cannabis.

Cannabis intensifies the drowsiness caused by the antihistamines in allergy medicines. Dizziness, confusion and difficulty concentrating may also occur as well as a reduction in judgements and motor coordination.

DMT and mushrooms are both psychedelics and will thus have additive effects when taken together. Be careful as the doses will quickly become overwhelming.

GHB and LSD is not usually a harmful combination, but it will tend to decrease the effects of both drugs.

Be careful when taking amphetamines (e.g. Adderall) and cocaine together. Both are stimulants, which increases the strain on your heart and places you at higher risk of overdosing. Cocaine will also mildly block the effects of the amphetamines4,21.

This combination carries a low risk. Paracetamol and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is a low risk when drinking a moderate amount of alcohol when using the recommended dose of paracetamol.

Avoid alcohol if you are taking paracetamol for a headache. Alcohol is likely to make a headache worse as it causes dehydration.

DMT and opioids is an unsafe combination. Low doses seem to counter the effects of hallucinogens, whereas higher doses potentiate them. Be careful with tramadol as it is known to lower the seizure threshold and psychedelics can sometimes cause seizures. Read more [here](http://www.ncbi.nlm.nih.gov/pubmed/3006089).

Be careful when taking allergy meds and cocaine together. There is some evidence that certain allergy medications combined with cocaine can increase reinforcement (i.e. how strongly you feel the need to take more of the drug). Both have similar effects which puts at increased risk of overstimulation. If you mix, start low and go slow53-56.

Aspirin and MDMA taken together may cause a greater increase in body temperature and sweating than is normal. This poses the greatest risk when dancing in crowded conditions. Take a break periodically to cool down.

These combinations are considered extremely harmful and should always be avoided. Reactions to combining these drugs are highly unpredictable and can potentially cause death.

Tramadol lowers the seizure threshold and thus should not be combined with any psychedelics, MAOIs, amphetamines and substituted amphetamines, or other opioids.

Be careful when taking mushrooms and cocaine together. You may experience anxiety. Some of their physiological effects oppose each other which puts strain on your body and makes it easier for you to overdose, especially during the comedown. If you mix, start low and go slow41,42.

Cannabis and DMT is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

Taking the combined oral contraceptive pill and cocaine together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively46,47.

Alcohol and GHB is an unsafe combination. Even in very low doses this rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.

Avoid benzos if you are taking allergy medicines. benzos and allergy medicines such as Benadryl, Piriton and Clarityn are depressants and both slow down your central nervous system. This can produce heightened side effects such as drowsiness, sedation and poor concentration. In extreme cases, loss of consciousness and may occur.

Using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before mixing drugs.

Effects will be stronger than taking either drug alone, however, it’s unlikely that there will be any adverse health reactions to this combination.

There is no evidence to date showing interactions between ibuprofen and benzos. This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Be careful when taking paracetamol and cocaine. Paracetamol may increase the harmful effects of cocaine on the liver4.

_Kratom leaves produce complex opioid-like analgesic effects, which could be potentiated with the use of ibuprofen._

Stimulants should not be combined with kratom, as they further increase the level of stimulation provided by the kratom. This results in the development of potentially severe side effects: anxiety, heart palpitations, excessive sweating, and general agitation. More life-threatening side effects that may result include: increased blood pressure. The lowering of the seizure threshold may also be observed.

[**Tramadol**](https://www.drugs.com/tramadol.html) can result in seizures when taken with LSD, as Tromadol lowers the seizure threshold.

These two drugs potentiate each other strongly and unpredictably which might lead to memory loss, blackout and respiratory depression.

Be careful when taking GHB with cocaine. Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind30,31.

Taking LSD and cocaine together is likely to cause overstimulation and anxiety. This combination will put strain on your heart and circulatory system and increase your risk of seizure. High doses will put you at risk. If you mix, start low and go slow37.

Cannabis and LSD is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

2C-X and GHB is not usually a harmful combination, it will tend to decrease the effects of both drugs. Be careful as 2C-X has mild stimulant effects which can cover the depressant effects of GHB.

Be careful when taking these drugs together, there is a considerable risk of a bad experience or overdose. If you mix, start low and go slow.

We strongly recommend you avoid taking DXM and cocaine together. Your blood pressure and heart rate are likely to increase to dangerous levels. You are at increased risk of experiencing blackouts. You may also experience anxiety and panic attacks28,29.

There is no evidence to date showing interactions between paracetamol and MDMA. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

If there’s one thing that can really be dangerous, it’s mixing drugs. We’ve compiled here the safety profiles of various mixes with nicotine (legal and illegal) but don’t swear by them. As with all matters drug-related, everyone is different and you can very easily experience an unexpected adverse reaction. If you’re taking medication, you need to be extremely wary when taking illegal drugs. Their interactions with prescribed medication are often poorly researched and you will definitely not be warned by your doctor about it.

- Using with other **stimulants** can cause an increased heart rate (_amphetamines_, _caffeine_, _cocaine_, _MDMA_)
- Combination with **depressants** can put a strain on the heart (_alcohol_, _opioids_, _Benzos_, _Ketamine_)
- Nicotine reduces the effectiveness of these medications: clozapine, fluvoxamine, olanzapine, tacrine, theophylline, caffeine[^16]. This means that it’s incredibly important to be honest with your doctor about how much you use nicotine and to let them know if you’re planning to cut down or quit.
- Hormonal contraceptives are contraindicated in women ≥35 y.o. smoking ≥15 cigarettes/day due to increased compound risk of cardiovascular diseases[^16].

Nicotine acts as a stimulant and is typically taken by users to increase sensations of alertness, euphoria and reduce feelings of anxiety. These positive mood states accentuated by stimulants are followed by a recovery period, during this time negative moods are experienced. While smokers report feeling more alert and less stressed following the first cigarette of the day, between cigarettes they feel less focused and more irritable or anxious.

Regular smokers crave nicotine again within 20 minutes to an hour of smoking due to the rapid changes in mood, this is why a typical consumption pattern for someone who smokes is 10-30 cigarettes/day. As with other stimulant drugs, the body’s tolerance to nicotine builds quickly and regular tobacco users will require more nicotine to function day-to-day.

When there is a high amount of nicotine consumed acutely users can feel nauseous, dizzy and restless. Withdrawal symptoms from nicotine tend to be amplified symptoms of the feelings experienced between cigarettes and can include difficulty sleeping, concentrating, depressed mood and headaches.

Here are the most common effects, not everyone necessarily experiences all of them every time they consume the drug and other effects not listed might be felt. **The likelihood of experiencing negative effects is far greater at high doses.**

The effects are (from positive to negative):

>>> effects 
++  Mild analgesic (at low dose)
++  Improved mental focus and productivity
++  Euphoria
++  Relaxation (anxiolytic)
++  Group identity
-- Increased heart rate
-- Nausea
-- Dizziness
-- Sleep disturbances
-- Tremors
<<<

### Nicotine Overdose  

A nicotine overdose (as a result of e.g. multiple nicotine lozenges) can be very harmful or fatal and requires immediate medical attention. The CDC states that about 50mg of nicotine is potentially deadly for the average adult [^21] [^22]. The first signs of a nicotine overdose include nausea, vomiting, abdominal pain, fast heartbeat, high blood pressure, difficulty breathing, agitation and seizures. If the overdose is significantly over the recommended intake or left untreated, people can go onto develop serious issues like an abnormal or very slow heartbeat, muscle paralysis and coma.[^19] [^20]

### How? How Much? When? For how Long?

As with any drug, the correct dose for you depends on factors such as weight, gender, metabolism, whether you have taken the drug recently or not, amongst many others.

**Read our section on dosing and tolerance in** [**ME**](https://www.drugsand.me/me/dosing) **for more information.**

### How you take it matters...

There are various ways of consuming nicotine, some more harmful than others.[^7] [^8]

Smoking is both the most popular and the most addictive method of consuming nicotine; delivering nicotine to the brain within seconds.

- **Tobacco cigarettes**: Cigarettes are made from dried and processed tobacco leaves, with some additives. As a result of combustion, tobacco smoke contains many carcinogens which are the main culprit for premature death.
- **Cigars and Pipes**: Most smokers only partly inhale the smoke, drawing it into the mouth but not the lungs, making cigars and pipes slightly less harmful than traditional cigarettes.
- **Hookah**: Non-filtered smoke is generated from a water-based smoking device and is flavoured and sweetened. Regular hookah smoking confers the same tobacco-associated health risks.
- **Electronic cigarettes** (_e-cigs_/_vapes_, including brands such as iQOS and Juul): Electronic, combustion-free devices delivering vaporised liquid, containing different percentages of nicotine. Preliminary findings suggest they are much less harmful than cigarettes, but can be more addictive due to the pleasant flavours added.

Other ways:

- **Snus**: tobacco placed on the gum for nicotine absorption. Safer alternative to smoking as it causes no lung damage, involves almost no carcinogens, and doesn’t affect those around you (i.e. second-hand smoking).
- **Chewing tobacco** (_e.g. gutkha_)**:** Thought to be more dangerous than snus, and strongly linked to causing oral cancer.
- **Snuffing tobacco** (_snuff_): involves powdered tobacco inhaled up the nose. Although it confers a lower overall harm than cigarettes, it’s still linked to an increased risk of cancer of the nose, mouth and throat.
- **Dissolvable tobacco** (_e.g. sprays, lozenges, chewing gums, nicotine patches_): mostly used during smoking cessation as ‘nicotine replacement therapies’

### How much?

It’s difficult to talk about nicotine dosage because it’s very person-dependent. Using nicotine is legal and, in most cases, a sociable act. This means that you get a significant range in how often or heavily people use it. The average cigarette contains 10-14mg of nicotine but you only actually inhale about 1-2mg[^18]. The best way to understand nicotine dosing is by looking at how much nicotine a doctor will prescribe for some trying to quit smoking. The [BNF](https://bnf.nice.org.uk/drug/nicotine.html) advises 2mg, whenever cravings arise, for someone who smokes less than 20 cigarettes a day and 4mg for someone who smokes more than 20. Take this into account when purchasing nicotine products to avoid a nicotine overdose.

### When do the effects kick in?

**Onset**: when inhaled, nicotine reaches the brain within 10-20 seconds[^14].

**Duration**: Nicotine has a half-life of 1-2 hrs, and so the effects wear off after a few hours[^15].

**Onset of craving/withdrawal symptoms**: Cravings, as well as withdrawal symptoms, can set in as soon as the last dose of nicotine is cleared from the body. This is about 4 hours after the last cigarette.

### How often can I take it?

New reports have shown that smoking even 1 cigarette a day confers a significant increased risk for cardiovascular diseases, stroke and lung cancer.[^11] [^12] Social smoking can also confer significant risk for the same conditions and is advised to be kept at a minimum.[^12]

Smoking tobacco or consuming nicotine can lead to a rapid, insidious nicotine-dependence and quitting can be extremely difficult, with very high rates of relapse. The majority of smokers want to quit but find that they cannot. So, it’s important that you:

**Resist peer pressure**: Most people are introduced to smoking by friends, often quite young. Remember that you can still go out for a “smoke break” with your friends without actually smoking. If you’re concerned about second-hand smoke or that you’ll be too tempted, skip these altogether.

**Don’t start smoking:** Smoking tobacco or vaping nicotine might look like a fun shared activity between friends, but it is highly addictive and comes with many serious health risks when done regularly.

**Minimise consumption**: Nicotine addiction can be a slippery slope, so minimise tobacco consumption as much as you can. A good way to keep smoking to a minimum is by refraining from buying your own pack of cigarettes (although your friends might hate you!). Additionally, try to use as little tobacco in joints with cannabis as possible, and resist the urge to smoke after drinking.

**If addicted, quit as soon as possible**: Quitting can be difficult but there are many options to get support. Talk to your pharmacist and doctor, and make sure to seek support from friends and family. Different methods work for different people, but some evidence suggests that stopping smoking completely and abruptly is the most effective. Many people fail on their first attempt but go on to kick the habit, so try to not get discouraged. Nicotine replacement therapies can help steadily wean you off of nicotine by slowly reducing your nicotine dependence.

**Switch to less harmful nicotine-delivery products**: E-cigarettes are safer alternatives to standard cigarettes, while snus and nicotine/patches/lozenges are even safer. It’s good to switch to smokeless tobacco as soon as possible to minimise the health risks.

If you think you may be addicted to nicotine, you can take the [Fagerstrom test for nicotine dependence](https://cde.drugabuse.gov/instrument/d7c0b0f5-b865-e4de-e040-bb89ad43202b). You can also talk to your doctor to find out more about potential interventions and drug treatment services. [Nicotine Anonymous](https://nicotine-anonymous.org/) is another good resource.

**Secondhand smoke:** Secondhand smoke is the combination of smoke from the burning end of a cigarette and the smoke exhaled by a smoker. The smoke burning from the end of a cigarette cigar actually contains more harmful substances than that inhaled by the smoker, as it does not pass through a filter.

Infants and children exposed regularly to secondhand smoke are exposed to a higher risk of permanent harms such as developing asthma, incomplete lung development and SIDS (Sudden Infant Death Syndrome). Children who grow up in a household with smokers are more likely to start using tobacco themselves.

Tobacco has been identified as the leading cause of preventable deaths by the World Health Organisation. It is responsible for over 7 million deaths per annum, 6 million of which are due to direct tobacco use and ~890000 resulting from second-hand smoke. Although nicotine is highly addictive, it does not contribute to the health risks listed below, and so smoke-free nicotine delivery methods are relatively safe when purchased from a reliable and safe retailer.

**Addiction**

Nicotine is extremely addictive, ranking as the 3rd most addictive drug after heroin & crack-cocaine. Almost 40% of people who start smoking become addicted, and there can be genetic vulnerabilities predisposing for nicotine dependence.[^4] [^5] Nicotine thus exposes smokers to the extremely harmful effects of tobacco smoking, which kills up to 50% of its users.[^9] Tobacco availability as well as the social context of smoking can contribute to high rates of exposure and fast transition to addiction. Alcohol has been shown to increase craving for tobacco in a dose-dependent way manner (i.e. nicotine cravings increase with the amount of alcohol consumed)[^13] and this can also speed up dependence.

Alarmingly, nicotine addiction causes permanent brain changes which are thought to increase the user’s sensitivity to the rewarding effects of other drugs, thus making them more vulnerable to addiction in general.

**Withdrawal**

Withdrawal is caused by your body craving nicotine and it can make it hard to quit because the symptoms can be unpleasant and hard to ignore. The effects of withdrawal aren’t life-threatening but it can take up to 3 months for your body to no longer crave nicotine.[^25] Just remember that you’re making a vital change that will have an incredibly positive impact on your overall health.

The symptoms of withdrawal include: anxiety, headaches, depressed mood, difficulty concentrating, restlessness and irritability [^26]. Withdrawal symptoms get worse with time until a normal balance is restored in the brain after abstinence. Slowly tapering down your nicotine requirements is an effective way to quit smoking because it can reduce withdrawal symptoms and reduce the likelihood of relapse.

**Cancer**

Since a causative link was first identified between smoking tobacco and lung cancer in the 1920s, extended research has universally confirmed that smoking tobacco significantly increases the risk of certain types of cancer[^9]: It confers a **_20-fold_** _increased risk_ of **lung cancer** and an _increased risk_ of **oral cancer**. This is mainly due to the 69 carcinogens found in tobacco smoke (including arsenic, benzene and lead), but additives commonly found in packet cigarettes are thought to contribute to this as well.[^10] Now it’s accepted that tobacco use can cause at least 15 different cancers.

**Other health risks**

There are various severe and fatal health conditions which can result from first-hand or second-hand smoking, listed below:

- **Increased risk of lung diseases** (e.g. chronic bronchitis, emphysema, asthma)
- **Risk of heart problems, CVD and stroke**: Carbon monoxide, which is produced via combustion, can damage the heart and blood vessels leading to blood vessel constriction and acute hypertension
- **Risk of diabetes**
- **Osteoporosis**
- **Foetal injury**: this can happen if the mother smokes during pregnancy
- **Sudden Infant Death Syndrome**: can result from second-hand smoking

Nicotine, although not directly linked to health problems such as cancer, has associated side effects which can be harmful. Nicotine can cause the following:

- **Atherosclerosis**
- **Peptic ulcers**
- Increased risk of **stroke**
- During pregnancy, it could confer risk for **obesity** and **type 2 diabetes** for the foetus

**Dangerous conditions**

If you have or have had cardiovascular problems, high blood-pressure, asthma, lung problems, or cancer it is not recommended to smoke as this will increase the risk of these conditions becoming worse or reappearing.

**Schizophrenia**

People affected by schizophrenia are thought to be more susceptible to nicotine addiction, and smoking constitutes the main reason for premature death among this group. Thus, if you have a family history or experiences of psychosis it’s advised to never start smoking tobacco.

**In the long-term...**

Smoking severely compromises quality of life in the long term, as it greatly reduces physical fitness and can in many cases cause erectile dysfunction in men. Fertility rates are decreased as a result of smoking in both sexes. It can also produce changes in physical appearance such as premature ageing, yellowing or rotting teeth and fingernails and can give rise to a foul breath. Furthermore, smoking can be very expensive and long-term users end up spending a significant portion of income to keep up their habit.

**EUROPE**: In most countries, the legal age for possession and public smoking is 16-18, while the legal age to buy tobacco is 18.

Exceptions to this:

- **Liechtenstein** (≥16 for both)
- **Kosovo** (No min. age for both)

**AMERICA**: Regional legislation varies greatly, with minimum age being 16, 17, 18, 19, and 21 in different states (For detailed information visit [https://en.wikipedia.org/wiki/Smoking\_age](https://en.wikipedia.org/wiki/Smoking_age))

**ASIA AND AUSTRALIA**: Most countries have either no legal age or a minimum age of 18 for possession, and a minimum age of 18 for purchasing tobacco.

Exceptions to this:

- **Bhutan**: Sale, cultivation and production of tobacco are **illegal**
- **Bangladesh** (≥16 for both)
- **Iraq** (No min. age for both)
- **Japan** (≥20 for both)
- **Mongolia** (≥21 for both)
- **North Korea** (≥17 for buying)
- **Singapore** (≥19 for both)
- **South Korea** (≥19 for possession, ≥20 for buying)
- **Sri Lanka** (≥21 for buying)
- **Turkmenistan**: Tobacco sales are **illegal**
- **Yemen** (No min. age for both)
- **Samoa** (≥21 for both)
- **Tokelau** (≥16 for both)

**AFRICA**: Most countries have no legal age for possession, but a minimum age of 18 for purchasing tobacco.

Exceptions to this:

- **Uganda** (≥21 for buying)
- **Algeria** (≥19 for buying)
- **Djibouti** (≥16 for buying)
- **São Tomé and Principe** (≥16 for buying)
- **Zambia** (≥16 for buying)
- **Cameroon** (No min. age for both)
- **Cape Verde** (No min. age for both)
- **Central African Republic** (No min. age for both)
- **Gambia** (No min. age for both)
- **Guinea-Bissau** (No min. age for both)
- **Lesotho** (No min. age for both)
- **Malawi** (No min. age for both)
- **Morocco** (No min. age for both)
- **Somalia** (No min. age for both)
- **South Sudan** (No min. age for both)
- **Tunisia** (No min. age for both)

Importantly, many of these countries, such as Australia and Russia, have smoking bans in place, prohibiting indoor smoking. You can read more about specific smoking bans here [https://en.wikipedia.org/wiki/List\_of\_smoking\_bans](https://en.wikipedia.org/wiki/List_of_smoking_bans).

Newer bans have been placed in some countries, prohibiting **electronic cigarettes** in some countries either altogether or if containing nicotine. These are as follows:

- **Argentina**: Banned
- **Australia**: Permitted, if without nicotine
- **Austria**: Banned
- **Belgium**: Permitted, if without nicotine
- **Brazil**: Banned
- **Brunei**: Banned (fine of $10,000 can be imposed)
- **Colombia**: Banned
- **Denmark**: Permitted, if without nicotine
- **Thailand**: Possession of e-cigarettes can be punishable by up to 10 years in prison.

Even one cigarette a day can increase the risk of heart disease and cancer.

Reconsider smoking

Nicotine can become addictive very quickly and it can be difficult to quit.

Keep it to a minimum

Other forms of nicotine avoid the harms associated with smoking or vaping, so they can be much safer.