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Taking both these drugs should not be harmful. The effects of both drugs are likely to be reduced.

Combining these drugs should not be harmful. However, they will mask each other’s effects, which might increase the risk of overdosing either drug. This combination is also hard on the heart due to each drug’s opposing action (7).

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Users have reported diminished experiences, thus care should be taken with dosage.

This combination carries a low risk. Aspirin and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Cannabis and DMT is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

There is no evidence to date showing interactions between paracetamol and 2C-B.

This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Taking both these drugs together is likely to cause an effect stronger than taking them individually. If used with care they are unlikely to cause an adverse or undesirable reaction.

We strongly recommend you avoid taking these drugs together, reactions are highly unpredictable and can be fatal. You will likely come to some degree of harm even if you take strong precautions.

Taking the combined oral contraceptive pill and cocaine together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively46,47.

Taking both of these drugs together is not usually any more harmful than taking them individually. The drugs are not known to interact with each other, each positively or negatively.

Alcohol and GHB is an unsafe combination. Even in very low doses this rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.

Be careful when mixing amphetamines and GHB. Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.

Avoid benzos if you are taking allergy medicines. benzos and allergy medicines such as Benadryl, Piriton and Clarityn are depressants and both slow down your central nervous system. This can produce heightened side effects such as drowsiness, sedation and poor concentration. In extreme cases, loss of consciousness and may occur.

These two drugs potentiate each other strongly and unpredictably which might lead to memory loss, blackout and respiratory depression.

Using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before mixing drugs.

Effects will be stronger than taking either drug alone, however, it’s unlikely that there will be any adverse health reactions to this combination.

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Users have reported diminished experiences thus care should be taken with dosage.

There is no evidence to date showing interactions between contraceptive pills and cannabis and generally this combination carries a low risk. However, cannabis will often intensify and alter your mood. If your contraception is causing significant changes in your mood, it is advisable to avoid cannabis as it may intensify mood swings.

This combination carries a low risk. Paracetamol and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is no evidence to date showing interactions between paracetamol and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between allergy medicines and LSD. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between ibuprofen and 2C-B. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

There is no evidence to date showing interactions between ibuprofen and benzos. This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before mixing drugs.

The effects of these two drugs are similar and synergistic, therefore mixing MDMA with 2C-B may increase the intensity of the experience.

Combining kratom with such depressants is contraindicated.Depressants have the same general effects as opiates. Therefore, combining them with kratom can cause a synergy effect of severe sedation, which can feel like overdosing. More sedation and respiratory depression can occur as a result. Memory blackouts are also likely to occur.

_Users report that the two herbs go well with each other, however, moderation is important when combining them. Keeping both doses low helps ensuring that you derive the highest possible positive effects without crossing the line to negative side-effects. You should go particularly light on cannabis dosage. Although rarely, some users report mild effects, such as feeling nauseous, sick and uncomfortable. Stronger side effects include anxiety and dizziness._

Be careful when taking paracetamol and cocaine. Paracetamol may increase the harmful effects of cocaine on the liver4.

Taking both these drugs together may produce unpleasant effects such as physical discomfort or overstimulation. High doses put you at risk. If you mix, start low and go slow

_Kratom leaves produce complex opioid-like analgesic effects, which could be potentiated with the use of ibuprofen._

Amphetamines and DMT is not usually a harmful combination but stimulants generally increase anxiety levels and the risk of thought loops which can lead to negative experiences.

Tricyclics (Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, and Vivactil) is consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into a fugue state where they wander away from home and don't know how they got there, and they are generally in a terrible state psychologically. Life-threatening seizures and at least one death have been reported to be triggered by the combination of LSD and tricyclics. If you are prescribed tricyclics for mental health problems, it is not a good idea to try LSD outside of a supervised medical setting, as it might worsen the symptoms.

Effects are additive. The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually.

This drug can have anxiogenic (anxiety-creating) effects which may create an unpleasant thoughts and discomfort.

Using these drugs together can cause an effect stronger than desired though they aren't likely to cause a serious adverse reaction if used carefully. Additional research should always be done before mixing drugs.

Using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Additional research should always be done before mixing drugs.

This combination is relatively safe and is unlikely to cause any unwanted effects.

Stimulants should not be combined with kratom, as they further increase the level of stimulation provided by the kratom. This results in the development of potentially severe side effects: anxiety, heart palpitations, excessive sweating, and general agitation. More life-threatening side effects that may result include: increased blood pressure. The lowering of the seizure threshold may also be observed.

Cannabis and mushrooms is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

The combination is unlikely to cause any adverse or undesirable reactions beyond those that might ordinarily be expected from taking these drugs individually. Benzos lessen the effects of nitrous oxide due to both drugs acting on common receptors.

This combination carries a low risk. Ibuprofen and cannabis are unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

Cannabis and LSD is not usually a harmful combination, but cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics so beware when mixing these drugs.

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Be careful when mixing these drugs.

The effects of mixing these two drugs together can be unpredictable.

There is no evidence to date showing interactions between aspirin and benzos. This combination is unlikely to cause an adverse or undesirable reaction when used carefully and within the recommended dose.

There is a low risk when drinking a moderate amount of alcohol when using the recommended dose of aspirin.

Avoid alcohol if you are taking aspirin for a headache. Alcohol is likely to make a headache worse as it causes dehydration.

2C-X and GHB is not usually a harmful combination, it will tend to decrease the effects of both drugs.

_Reactions and side effects are rare, but using these drugs together can cause an effect stronger than taking them individually, and they aren't likely to cause an adverse or undesirable reaction when used carefully. Kratom’s effects are due primarily to its interaction with mu-receptors in the brain, while SSRIs produce their effects by interacting with the serotonin receptors. It is hypothesized that, since both act on receptors that can sometimes be involved with each other in certain processes, an interaction may or may not occur. Interactions include risks such as_ [_serotonin syndrome_](https://www.mdedge.com/ccjm/article/120386/neurology/serotonin-syndrome-preventing-recognizing-and-treating-it)_. Additional research should always be done before mixing drugs._

[**Tramadol**](https://www.drugs.com/tramadol.html) can result in seizures when taken with LSD, as Tromadol lowers the seizure threshold.

There is no evidence to date showing interactions between ibuprofen and modafinil. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Taking aspirin and cocaine together is not usually any more harmful than taking them individually. Aspirin is sometimes [used](https://www.the-hospitalist.org/hospitalist/article/125897/how-should-patient-cocaine-associated-chest-pain-be-treated) by doctors in response to cocaine associated chest pains51,52.

There is no evidence to date showing interactions between ibuprofen and ketamine. This combination is unlikely to cause an adverse or undesirable reaction when used carefully.

Caffeine and GHB have low risk and decreased synergy. Caffeine will mildly hide the depressant effects of GHB leading to a slightly increased risk of overdose.

### How? How Much? When? For how Long?

As with any drug, the correct dose for you depends on factors such as weight, gender, metabolism, whether you have taken the drug recently or not, amongst many others. Read our Dosing and Tolerance section in [**Me**](https://drugsand.me/en/me/dosing/) for more information.

### How you take it matters...

The most common method to alcohol consumption is oral, which we recommend as it is the best way to gauge how much you've had. Recently new trends, such as inhaling, have appeared but these are ill-understood and can be very dangerous. If you want to learn more about how the method of administration affects you, read our [**Me**](https://drugsand.me/en/me/taking-them/) section.

### How much?

Alcohol is metabolised relatively quickly, however, it is more difficult for the body to get rid of the toxins with increasing alcohol dosages. Therefore, we suggest to limiting your alcohol doses if you want to be on the safe side!

People are advised not to regularly drink more than **14 units a week**. Spread your drinking over three days or more if you drink as much as 14 units a week.

### What is a unit in the UK?

![alcohol-units.png](/uploads/alcohol_units_c1ab499a41.png)

__Source:__ [NHS](http://www.nhs.uk/Livewell/alcohol/Pages/alcohol-units.aspx)

[**Take this quiz**](http://drinksmeter.com/) **on Quizmeter to compare how much you drink to others like you.**

### When do the effects kick in?

-   **Total duration:** 1.5 - 3 hrs
-   **Onset:** 15 - 30 mins
-   **Coming up:** 15 - 20 mins
-   **Plateau:** 30 - 90 mins
-   **Coming down:** 45 - 60 mins

__Source:__ [erowid.org](http://www.erowid.org/)

>>> tabs
# Before
1.  Carry condoms.
2.  Eat before you drink and stay hydrated; it can reduce the chances of getting a hangover or accidentally drinking over your limit.
3.  Don’t go out drinking alone, this will increase the chance of unpleasant experiences, unsafe circumstances, and risky behaviour.
4.  Avoid drinking out of impulse because of reaction to anger, this can lead to bad drinking episodes.
5.  To control for diseases such as cancer, the best policy is to reduce the amount of alcohol that is taken. You can do this by counting the drinks you have in a day and set targets to reduce them.

# During
1.  Don’t drink and drive. As easy as it sounds, people still do it, causing hundreds of thousands of deaths per year.
2.  Control the amount of drinks you have and the speed at which you drink them if you are susceptible to blackouts.
3.  Avoid getting drinks spiked with other drugs by following [**simple steps**](http://www.wikihow.com/Avoid-Spiked-Drinks).

#### In an emergency or overdose

- Stay calm and try to not look anxious in front of the person that needs help. Before approaching or touching the person, explain what you intend to do in a direct and reassuring manner.
- Keep the person still and comfortable. Don't let him/her walk alone.
- Do not administer any food, drink or medication --including aspirin or vitamins --which may cause stomach distress.
- Do not ridicule or threaten the person.
- Do not let the person sleep on his/her back. Death from choking on inhaled vomit may result. Place the person on his/her side, with one arm extended above the head. Keep a sober person nearby to watch for signs of trouble.

**Important:** Remember, only time will help to sober a person who is intoxicated. Walking, black coffee or a cold shower will not help. Drink plenty of water to avoid dehydration, and reduce the hangover.

#### Seek medical attention if:

- The person is unconscious and cannot be wakened
- Breathing is irregular and/or shallow
- You suspect alcohol has been mixed with other drugs
- Skin is clammy or pale
- Blood in vomit

_Source:_ [***Erowid***](https://www.erowid.org/chemicals/alcohol/alcohol_health.shtml)

# After 

Alcohol hangovers are considered to be worse than the day-after effects of nearly any other drug. Alcohol causes liver damage. Bad hangovers may indicate alcohol toxicity and should be avoided.

Occasional drinkers are more likely to get bad hangovers than regular ones.

They usually last for 1-36 hours.

The after effects include:

- Headache
- Bad mood
- Thirst
- Nausea, vomiting, and/or dry-heaves
- Dizziness that becomes worse with movement
- Loud noises and bright lights cause pain/discomfort
- Inability to think clearly
- Muscle fatigue and pain
- Sweating and tremors

_Source:_ [***Erowid***](https://www.erowid.org/chemicals/alcohol/alcohol_hangover.shtml)

The best way to reduce hangover effects is to drink water before, during and after the night. However, this will not completely remove it as it isn't just caused by dehydration.

Regarding vitamin B supplements, there is [**no evidence**](http://www.livestrong.com/article/535207-how-to-prevent-hangover-with-vitamin-b-complex/) that these actually ‘cure’ hangovers, although they may work as a placebo.
<<<

Due to its legal status, alcohol consumers wrongly classify the drug as ‘safe’, as it has been approved for consumption. The truth is that due to a drug safety measure (active dose/lethal dose), we know that alcohol is actually one of the most dangerous recreational drugs. Why? This concept compares how much you have to drink to get drunk to how much you have to drink to die, and alcohol has the highest level.

Here are the most common effects of alcohol. You won’t necessarily experience all these effects, every time you consume the drug, and it is possible that you may feel other effects not listed here.

The effects are (from positive to negative):

>>> effects 
++   Relaxation
++   Happiness
++   Increased sociability
==   Slurred speech
==   Flushed skin
==   Sleepiness
==   Blurry, distorted vision
==   Higher impulsivity
--   Decreased coordination
--   Nausea, vomiting (vomiting while unconscious can kill! If a friend is unconscious due to alcohol, position the person in the recovery position)
--   Reduced ability to judge own impairment
--   Emotional volatility (anger, violence, sadness, etc)
--   Sexual dysfunctions (e.g. erectile dysfunction or difficulty reaching orgasms)
--   Dizziness and confusion
--   Blackouts and memory loss at high doses
<<<

### Signs of dependence

Contrary to popular belief, alcohol is an incredibly addictive drug. If you think you might be dependent on alcohol, these websites might be useful:

- [**Addaction UK**](http://www.addaction.org.uk/)
- [**Alcoholics Anonymous UK**](http://www.alcoholics-anonymous.org.uk/)

### In the long term

- Increase risk of oral, throat, colon, liver, and breast [**cancer**](http://www.ncbi.nlm.nih.gov/pubmed/16557583?dopt=Abstrac)
- [**Cirrhosis**](http://www.ncbi.nlm.nih.gov/pubmed/16399153?dopt=Abstract) of the liver
- [**Fetal alcohol syndrome**](http://www.ncbi.nlm.nih.gov/pubmed/16737465?dopt=Abstract) if used by pregnant women in large quantities
- [**Fatty Liver Disease**](http://www.ncbi.nlm.nih.gov/pubmed/16481976?dopt=Abstract)
- Injuries from accidents, falls, motor vehicle accidents, etc.
- [**Coma and death**](http://www.ncbi.nlm.nih.gov/pubmed/15301405?dopt=Abstract) at extreme doses

### FAQs

#### Should I consume alcohol to protect from heart problems?

There is evidence to suggest that low and moderate drinking (i.e., within the lower risk guidelines) can protect against coronary heart disease, but it is a relatively small effect and it's best to try other, safer methods first.

#### Does drinking water cancel out the effects of alcohol?

Water or soft drinks do not cancel the effects of alcohol. However, they do slow down the pace of alcohol intake. Water also helps reducing the dehydration, helping the hangover next morning.

#### Does mixing drinks makes you more drunk?

Mixing drinks does not cause your hangover as the alcohol content does not change. However, mixing can irritate the stomach even more, leading to unpleasant side effects.

#### Does coffee sober you up?

Coffee can make you more alert and awake, but does not reduce the effects caused by alcohol. This makes drunk driving especially dangerous due to the impaired judgement and the perceived state of alertness caused by the coffee.

__Source:__ [http://drugscience.org.uk/drugs/depressants/alcohol](http://drugscience.org.uk/drugs/depressants/alcohol)

### Useful links

-   [**Join Club Soda UK**](http://www.joinclubsoda.co.uk/)

### References

[^1]:  Nutt, D. J., King, L. A., & Phillips, L. D. (2010). [Drug harms in the UK: a multicriteria decision analysis.](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61462-6/fulltext) _The Lancet_, _376_(9752), 1558-1565.

Drink some water after each drink. You will reduce the chances of overdrinking and getting hangovers!

Drink water

If you are mixing with another substance, make sure its not a dangerous combination.

Careful mixing

Always practice safe sex; take a condom with you.

Alcohol

{Booze, liquor, spirits, wine, beer, cocktails, long drinks}

Dose and onset

How? How Much? When? For how Long?

How you take it matters...

How much?

What is a unit in the UK?

When do the effects kick in?